The new SusChem Strategic Innovation and Research Agenda (SIRA) focuses on technology priorities towards 2030, across advanced materials, advanced processes as well as the implementation and co-development of enabling digital technologies. Horizontal topics are equally addressed, including sustainability assessment innovation, safe-by-design for chemicals and materials, as well as building on education and skills capacity in Europe. The SIRA is the result of a co-creation process together with stakeholders across the innovation ecosystem. It outlines the strategic Research and Innovation (R&I) priorities, with a strong relevance to sustainable chemistry, linking to Horizon Europe and beyond.